DcR3/TNFRSF6B, Human (sf9, hFc)

DcR3 is a secreted member of the Tumor Necrosis Factor (TNF) receptor superfamily, recognized as a significant anti-apoptotic factor with prominent involvement in various inflammatory and neoplastic conditions. DcR3 can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL against apoptosis[1][2][3]. DcR3 has been associated with tumorigenesis and metastasis, via DcR3/STAT1/IRF1 feedback loop[4][5]. DcR3/TNFRSF6B Protein, Human (sf9, hFc) has a full length of 300 amino acids (M1-H300), produced in sf9 insect cells with C-terminal hFc-tag.

Product Specifications

Product Name Alternative

DcR3/TNFRSF6B Protein, Human (sf9, hFc), Human, Sf9 insect cells

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/dcr3-tnfrsf6b-protein-human-sf9-hfc.html

Purity

95.80

Molecular Formula

8771 (Gene_ID) O95407 (V30-H300) (Accession)

Molecular Weight

Approximately 65 kDa

References & Citations

[1]Zhan C, et al. Decoy strategies: the structure of TL1A:DcR3 complex. Structure. 2011 Feb 9;19 (2) :162-71.|[2]Lagou S, et al. The Role of Decoy Receptor DcR3 in Gastrointestinal Malignancy. Cancer Diagn Progn. 2022 Jul 3;2 (4) :411-421.|[3]Ge H, et al. DcR3 induces proliferation, migration, invasion, and EMT in gastric cancer cells via the PI3K/AKT/GSK-3β/β-catenin signaling pathway. Onco Targets Ther. 2018 Jul 19;11:4177-4187.|[4]Liu YP, et al. DcR3 induces epithelial-mesenchymal transition through activation of the TGF-β3/SMAD signaling pathway in CRC. Oncotarget. 2016 Nov 22;7 (47) :77306-77318.|[5]Gao L, et al. DcR3, a new biomarker for sepsis, correlates with infection severity and procalcitonin. Oncotarget. 2017 Dec 28;9 (13) :10934-10944.