LTV-1
LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM. LTV-1 has the potential for autoimmunity treatment[1].
Product Specifications
CAS Number
347379-29-7
UNSPSC
12352005
Hazard Statement
H302, H400
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/LTV-1.html
Purity
98.0
Solubility
DMSO : 22.73 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=CC(COC2=CC=C(/C=C(C(N3C4=CC=CC=C4C)=O)\C(NC3=S)=O)C=C2)=C1
Molecular Formula
C26H20N2O5S
Molecular Weight
472.51
Precautions
H302, H400
References & Citations
[1]Vang T, et al. LYP inhibits T-cell activation when dissociated from CSK. Nat Chem Biol. 2012 Mar 18;8 (5) :437-446.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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