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Salvinorin B

Salvinorin B is a selective and brain-penetrant kappa opioid receptor (KOPr) agonist with an EC50 of 248 nM and Ki of 2.95 μM. Salvinorin B activates downstream signaling pathways by binding to KOPr, inhibits pain transmission and reduces inflammatory response. Salvinorin B can be used for the researches of inflammation, immunology and neurological disease, such as neuropathic pain, multiple sclerosis and anxiety[1][2][3][4][5].

Product Specifications

UNSPSC

12352005

Target

Opioid Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/salvinorin-b.html

Purity

99.90

Solubility

DMSO : 10 mg/mL (ultrasonic; warming)

Smiles

C[C@@]12[C@@]3([C@](CC[C@]1(C(O[C@@H](C2)C4=COC=C4)=O)[H])(C)[C@H](C(OC)=O)C[C@@H](C3=O)O)[H]

Molecular Formula

C21H26O7

Molecular Weight

390.43

References & Citations

[1]Paton KF, et al. The analgesic and anti-inflammatory effects of Salvinorin A analogue β-tetrahydropyran Salvinorin B in mice. Eur J Pain. 2017 Jul;21 (6) :1039-1050.|[2]Paton KF, et al. The Salvinorin Analogue, Ethoxymethyl Ether Salvinorin B, Promotes Remyelination in Preclinical Models of Multiple Sclerosis. Front Neurol. 2021 Dec 20;12:782190.|[3]Moreira CVL, et al. Heteroaromatic salvinorin A analogue (P-3 l) elicits antinociceptive and anxiolytic-like effects. Fitoterapia. 2023 Jun;167:105488.|[4]Kivell BM, et al. Kappa Opioid Receptor Agonist Mesyl Sal B Attenuates Behavioral Sensitization to Cocaine with Fewer Aversive Side-Effects than Salvinorin A in Rodents. Molecules. 2018 Oct 11;23 (10) :2602.|[5]Vardy E, et al. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron. 2015 May 20;86 (4) :936-946.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-110252/Salvinorin-B-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-110252/Salvinorin-B-SDS-MedChemExpress.pdf

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

κ Opioid Receptor/KOR

CAS Number

[92545-30-7]

Available Sizes

Curated Selection

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