Denatonium (benzoate)

Denatonium benzoate (THS-839) is known as the most bitter compound and is commonly used as a deterrent (bittering agent) to activate different types of bitter taste receptors (TAS2Rs) with oral activity. Denatonium benzoate can enhance insulin secretion, has anti-inflammatory effects, and promotes allergy susceptibility[1] [2] [3][4].

Product Specifications

CAS Number

[3734-33-6]

Product Name Alternative

THS-839

UNSPSC

12352005

Hazard Statement

H302, H412

Target

Taste Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Denatonium-benzoate.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : 20 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)

Smiles

CC[N+](CC)(CC(NC1=C(C)C=CC=C1C)=O)CC2=CC=CC=C2.O=C([O-])C3=CC=CC=C3

Molecular Formula

C28H34N2O3

Molecular Weight

446.58

Precautions

H302, H412

References & Citations

[1]Plamen I Zagorchev, et al. Denatonium benzoate decreases the effect of histamine in vitro and in rats. Tropical Journal of Pharmaceutical Research September.2020; 19 (9) : 1879-1885. |[2]Huaping Xu, et al. Denatonium Benzoate Exposure Promotes IgE-Mediated Mast Cell Degranulation and Allergy By Upregulating FcεRIα Expression.Hypothesis. posted 29 Sep, 2021 |[3]DALEE. KAUKEINEN, et al. Evaluation of aversive agents to increase the selectivity of rodenticides with emphasis on denatonium benzoate (Bitrex) bittering agent. eScholarship. Proceedings of the Vertebrate Pest Conference, 15 (15) |[4]Weikun Huang, et al. Effects of a bitter substance, denatonium benzoate, on pancreatic hormone secretion. Am J Physiol Endocrinol Metab. 2024 Apr 1;326 (4) :E537-E544.