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CDK12/13 ligand 1

ALK-IN-29 (compound 4c) has a certain inhibitory effect on tyrosine protein kinases ALK, CDK2/CyclinE1 and FAK, among which the strongest inhibitory effect on ALK kinase is 40.63% at a concentration of 10 μM. ALK-IN-29 can be used for anti-cancer research[1].

Product Specifications

CAS Number

2244986-40-9

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk12-13-ligand-1.html

Smiles

O=C(N([C@@H]1CC[C@H](CC1)NC2=CC=C(C=N2)C#N)C3=CC=C(Br)C=C3)NCC4=CC=CC=C4

Molecular Formula

C26H26BrN5O

Molecular Weight

504.42

References & Citations

[1]Zhou L, et al. Discovery of ZLC491 as a Potent, Selective, and Orally Bioavailable CDK12/13 PROTAC Degrader. J Med Chem. 2024 Oct 24;67 (20) :18247-18264.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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