NADPH

NADPH is a coenzyme of glutathione reductase (GR), thioredoxin reductase (TrxR) and NADPH oxidase (NOX), and participates in redox reactions as a hydrogen donor. NADPH has the characteristic of selectively participating in the regulation of cellular redox homeostasis. NADPH exerts antioxidant activity and resists reactive oxygen species (ROS) damage by providing reducing equivalents for the regeneration of glutathione (GSH) and thioredoxin (Trx) ; at the same time, it acts as a substrate of NOX to generate superoxide anions, mediating oxidative stress and immune response. NADPH participates in maintaining the intracellular reducing environment, biosynthesis and regulating gene expression (such as the Nrf2 pathway), and is mainly used in the study of oxidative stress-related diseases (such as cardiovascular diseases, neurodegenerative diseases, cancer) and immune regulation mechanisms[1][2].

Product Specifications

CAS Number

[53-57-6]

Product Name Alternative

EPZ015866; GSK3203591

UNSPSC

12352005

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nadph.html

Purity

99.75

Solubility

H2O : 116.67 mg/mL (ultrasonic)

Smiles

O=P(O)(O)O[C@H]1[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]([C@H]1O)COP(OP(OC[C@H]4O[C@@H](N5C=C(CC=C5)C(N)=O)[C@@H]([C@@H]4O)O)(O)=O)(O)=O

Molecular Formula

C21H30N7O17P3

Molecular Weight

745.42

References & Citations

[1]Xia W, et al. Roles of NAD (+) /NADH and NADP (+) /NADPH in cell death. Curr Pharm Des. 2009;15 (1) :12-9.|[2]Pollak N, et al. NAD kinase levels control the NADPH concentration in human cells. J Biol Chem. 2007 Nov 16;282 (46) :33562-33571.