α-Synuclein inhibitor 10

α-Synuclein inhibitor 10 (compound a8) inhibits the activity of α-Syn aggregation with low IC50 value (1.08 μM) . α-Synuclein inhibitor 10 exhibits good binding affinity to α-Syn residues. α-Synuclein inhibitor 10 can be used in the research of Parkinson's disease (PD) [1].

Product Specifications

CAS Number

[3050715-65-3]

UNSPSC

12352005

Target

α-synuclein

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/α-synuclein-inhibitor-10.html

Purity

99.85

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C(C=C1C2=O)=CC(O)=C1C(C3=C2C=CC=C3O)=O)NC4=CC=C(Cl)C=C4O

Molecular Formula

C21H12ClNO6

Molecular Weight

409.78

References & Citations

[1]Wei Zhang, et al. The potential of Rhein's aromatic amines for Parkinson's disease prevention and treatment: α-Synuclein aggregation inhibition and disaggregation of preformed fibers. Bioorg Med Chem Lett. 2024.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

α-synuclein Aggregation

Available Sizes

Curated Selection

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