[Glp5, (Me) Phe8, Sar9] Substance P (5-11)

[Glp5, (Me) Phe8, Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5, (Me) Phe8, Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5, (Me) Phe8, Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats[1][2][3].

Product Specifications

CAS Number

[77128-69-9]

Product Name Alternative

DiMe-C7

UNSPSC

12352209

Target

Neurokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Metabolic Disease; Neurological Disease; Others

Assay Protocol

https://www.medchemexpress.com/glp5-me-phe8-sar9-substance-p-5-11.html

Purity

99.61

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC(CN(C)C([C@H](CC1=CC=CC=C1)N(C)C([C@@H](NC([C@H](CCC(N)=O)NC([C@@H]2CCC(N2)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O

Molecular Formula

C43H61N9O9S

Molecular Weight

880.06

References & Citations

[1]Elliott PJ, et al. Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area. Brain Res. 1986 Jan 15;363 (1) :145-7. |[2]Eison AS, et al. Substance P analog, DiMe-C7: evidence for stability in rat brain and prolonged central actions. Science. 1982 Jan 8;215 (4529) :188-90. |[3]Placenza FM, et al. Infusion of the substance P analogue, DiMe-C7, into the ventral tegmental area induces reinstatement of cocaine-seeking behaviour in rats. Psychopharmacology (Berl) . 2004 Dec;177 (1-2) :111-20.