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BRD-6929

BRD-6929 is a potent, selective brain-penetrant inhibitor of class I histone deacetylase HDAC1 and HDAC2 inhibitor with IC50 of 1 nM and 8 nM, respectively. BRD-6929 shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively. BRD-6929 can be used for mood-related behavioral model research[3].

Product Specifications

CAS Number

849234-64-6

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

HDAC; HIV

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Epigenetics

Applications

Neuroscience-Neuromodulation

Field of Research

Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/brd-6929.html

Concentration

10mM

Purity

99.01

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC(C2=CC=CS2)=CC=C1N)C3=CC=C(NC(C)=O)C=C3

Molecular Formula

C19H17N3O2S

Molecular Weight

351.42

Precautions

H315, H319, H320

References & Citations

[1]Li-Huei Tsai, et al. Inhibition of hdac2 to promote memory. patent/US20120101147|[2]Schroeder FA, et al. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and altersmouse behavior in two mood-related tests. PLoS One. 2013 Aug 14;8 (8) :e71323.|[3]Huang L, et al. Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. ACS Med Chem Lett. 2018 Feb 6;9 (3) :268-273.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HDAC1; HDAC2; HDAC3; HIV-1

Available Sizes

Frequently Asked Questions

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