Arecoline (hydrobromide)

Arecoline hydrobromide, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline hydrobromide exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrobromide also can induce oxidative stress[1][2][3][4].

Product Specifications

CAS Number

[300-08-3]

Product Name Alternative

Methyl 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylate hydrobromide

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAChR; nAChR

Type

Natural Products

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Arecoline-hydrobromide.html

Purity

99.95

Solubility

DMSO : ≥ 50 mg/mL|H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=CCCN(C)C1)OC.Br

Molecular Formula

C8H14BrNO2

Molecular Weight

236.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Thangjam GS, et, al. Regulation of oxidative-stress responsive genes by arecoline in human keratinocytes. J Periodontal Res. 2009 Oct;44 (5) :673-82.|[2]Liu YJ, et, al. The pharmacology, toxicology and potential applications of arecoline: a review. Pharm Biol. 2016 Nov;54 (11) :2753-2760.|[3]Volgin AD, et, al. DARK Classics in Chemical Neuroscience: Arecoline. ACS Chem Neurosci. 2019 May 15;10 (5) :2176-2185. |[4]Kuo TM, et, al. Arecoline induces TNF-alpha production and Zonula Occludens-1 redistribution in mouse Sertoli TM4 cells. J Biomed Sci. 2014 Sep 9;21 (1) :93.