Pelecopan
Pelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D with an IC50 value of 14.3 nM. Pelecopan can target factor D to prevent both intravascular and extravascular hemolysis in PNH. Pelecopan also be used for other alternative pathway (AP) mediated diseases[1][2][3].
Product Specifications
CAS Number
2378380-49-3
Product Name Alternative
BCX9930
UNSPSC
12352005
Target
Complement System
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pelecopan.html
Concentration
10mM
Purity
98.07
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CC1=C(OCC2=CC3=C(C(C4=C(F)C(CN)=NC=C4)=C2)OC=C3)C=CC=C1)O
Molecular Formula
C23H19FN2O4
Molecular Weight
406.41
References & Citations
[1]International Nonproprietary Names for Pharmaceutical Substances (INN) |[2]AustinKulasekararajMD MRCP, FRCPath, et al. BCX9930, a Potent, Selective, Oral Factor D Inhibitor, Demonstrates Proof-of-Concept As Monotherapy in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) . Blood (2020) Volume 136, Supplement 1, 5 November 2020, Pages 14-15|[3]XilinChenMDPhD, et al. Preclinical Characterization of BCX9930, a Potent Oral Complement Factor D Inhibitor, Targeting Alternative Pathway-Mediated Diseases Including Paroxysmal Nocturnal Hemoglobinuria (PNH) . Blood (2020) Volume 136, Supplement 1, 5 November 2020, Page 32.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
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