SEA0400

SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger (NCX), inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50s of from 5 to 33 nM.

Product Specifications

CAS Number

[223104-29-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H320, H335

Target

Na+/Ca2+ Exchanger

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/SEA0400.html

Purity

99.95

Solubility

DMSO : ≥ 32 mg/mL

Smiles

NC1=CC(OCC)=CC=C1OC2=CC=C(OCC3=CC(F)=CC=C3F)C=C2

Molecular Formula

C21H19F2NO3

Molecular Weight

371.38

Precautions

H302, H315, H320, H335

References & Citations

[1]Matsuda T, et al. SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models. J Pharmacol Exp Ther. 2001 Jul;298 (1) :249-56.|[2]Nashida T, et al. The specific Na (+) /Ca (2+) exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cells. Neurochem Int. 2011 Aug;59 (1) :51-8.|[3]Ago Y, et al. SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease. Neuropharmacology. 2011 Dec;61 (8) :1441-51.