CH5447240
Product Specifications
UNSPSC Description
CH5447240 is an agonist for parathyroid hormone receptor 1 (PTHR1), that inhibits human PTHR1 with an EC50 of 12 μM. CH5447240 exhibits good metabolic stability in human liver microsomes. CH5447240 increases serum calcium levels in rats. CH5447240 can be used in research about hypoparathyroidism[1].
Target Antigen
PTHR
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/ch5447240.html
Smiles
O=C(N)N(C1=CC(C)=C(CCS(=O)(N(CC2)CCC2(NC([C@H]3CC[C@H](C)CC3)=N4)C4=O)=O)C(C)=C1)C
Molecular Weight
517.68
References & Citations
[1]Nishimura Y, et al., Development of a Novel Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist (CH5447240), a Potent and Orally Available Small Molecule for Treatment of Hypoparathyroidism. J Med Chem. 2018 Jul 26;61(14):5949-5962.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120398/CH5447240-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120398/
Clinical Information
No Development Reported
CAS Number
1253919-92-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![APC Anti-Mouse CD49b/pan-NK cells Antibody[DX5]](https://cdn.genprice.uk/genprice/genprice4.png)