CH5447240
CH5447240 is an agonist for parathyroid hormone receptor 1 (PTHR1), that inhibits human PTHR1 with an EC50 of 12 μM. CH5447240 exhibits good metabolic stability in human liver microsomes. CH5447240 increases serum calcium levels in rats. CH5447240 can be used in research about hypoparathyroidism[1].
Product Specifications
CAS Number
1253919-92-4
UNSPSC
12352005
Target
PTHR
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/ch5447240.html
Smiles
O=C(N)N(C1=CC(C)=C(CCS(=O)(N(CC2)CCC2(NC([C@H]3CC[C@H](C)CC3)=N4)C4=O)=O)C(C)=C1)C
Molecular Formula
C26H39N5O4S
Molecular Weight
517.68
References & Citations
[1]Nishimura Y, et al., Development of a Novel Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist (CH5447240), a Potent and Orally Available Small Molecule for Treatment of Hypoparathyroidism. J Med Chem. 2018 Jul 26;61 (14) :5949-5962.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PTH1R
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