Abemaciclib (methanesulfonate)
Abemaciclib methanesulfonate (LY2835219 methanesulfonate) is a selective CDK4/6 inhibitor with IC50s of 2 nM and 10 nM for CDK4 and CDK6, respectively[1][2][3].
Product Specifications
CAS Number
[1231930-82-7]
Product Name Alternative
LY2835219 (methanesulfonate)
UNSPSC
12352005
Hazard Statement
H360, H373, H410
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LY2835219.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 125 mg/mL (ultrasonic)
Smiles
CC(N1C2=CC(C3=NC(NC4=NC=C(CN5CCN(CC)CC5)C=C4)=NC=C3F)=CC(F)=C2N=C1C)C.CS(=O)(O)=O
Molecular Formula
C28H36F2N8O3S
Molecular Weight
602.70
Precautions
H360, H373, H410
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
CDK1; CDK2; CDK4; CDK5; CDK6; CDK7; CDK9
Citation 01
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items