ONO-0300302

ONO-0300302 is an orally active and potent LPA1 (lysophosphatidic acid receptor 1) antagonist, with an IC50 of 0.086 μM. ONO-0300302 is a slow tight binding inhibitor, and its binding affinity increases with time, with Kd of 0.34 nM (37 °C, 2 h) . ONO-0300302 can be used for benign prostatic hyperplasia (BPH) research[1].

Product Specifications

CAS Number

[856689-51-5]

Product Name Alternative

CGS 10746

UNSPSC

12352005

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/ono-0300302.html

Concentration

10mM

Purity

98.02

Solubility

DMSO : 220 mg/mL (ultrasonic)

Smiles

O=C(O)CCC1=CN(C[C@H](CC2CC3=C(C=CC=C3)C2)[C@@H](C4=CC(OC)=C(C)C(OC)=C4)O)C=C1

Molecular Formula

C29H35NO5

Molecular Weight

477.59

References & Citations

[1]Terakado M, et al. Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia. ACS Med Chem Lett. 2017 Nov 20;8 (12) :1281-1286.