VU6043653
VU6043653 is a potent, selective and cross the blood-brain barrier metabotropic glutamate receptor subtype 5 (mGlu5) negative allosteric modulator with an IC50 value of 325 nM for hmGlu5[1].
Product Specifications
CAS Number
[3032791-06-0]
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu6043653.html
Purity
99.97
Solubility
DMSO : ≥ 25 mg/mL
Smiles
CC1=NC(C(NC2=CC=C(F)C=N2)=O)=CC(OC3=CN(C)N=C3)=C1
Molecular Formula
C16H14FN5O2
Molecular Weight
327.31
References & Citations
[1]Elizabeth S. Childress, et al. Discovery of 4- (5-Membered) Heteroarylether-6-methylpicolinamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5. ACS Med. Chem. Lett. 2024.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5
Available Sizes
Curated Selection
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