K-7174 (dihydrochloride)
Product Specifications
UNSPSC Description
K-7174 dihydrochloride is an orally active proteasome and GATA inhibitor. K-7174 dihydrochloride is a cell adhesion inhibitor. K-7174 dihydrochloride induces cell apoptosis. K-7174 dihydrochloride shows antitumor activities, it can be used for the research of cancer[1][2][3].
Target Antigen
Apoptosis; Proteasome
Type
Reference compound
Related Pathways
Apoptosis;Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/K-7174-dihydrochloride.html
Purity
98.60
Solubility
H2O : 15 mg/mL (ultrasonic;warming)
Smiles
COC1=C(OC)C(OC)=CC(/C=C/CCCN2CCN(CCC/C=C/C3=CC(OC)=C(OC)C(OC)=C3)CCC2)=C1.[H]Cl.[H]Cl
Molecular Weight
641.67
References & Citations
[1]Umetani M, et al. A novel cell adhesion inhibitor, K-7174, reduces the endothelial VCAM-1 induction by inflammatory cytokines, acting through the regulation of GATA. Biochem Biophys Res Commun. 2000 Jun 7;272(2):370-4.|[2]Imagawa S, et al. A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1beta, TNF-alpha, or L-NMMA. FASEB J. 2003 Sep;17(12):1742-4.|[3]Kikuchi J, et al. The novel orally active proteasome inhibitor K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulating the expression of class I histone deacetylases. J Biol Chem. 2013 Aug 30;288(35):25593-602.Biomaterials. 2021, 120967.|bioRxiv. 2019 Sep.|Cell Rep Med. 2022 Mar 15;3(3):100561.|Department of Molecular Medicine and Biopharmaceutical Sciences. 2020 May.|FASEB J. 2020 Mar;34(3):4462-4481.|J Assist Reprod Genet. 2024 Aug 15.|J Clin Invest. 2024 Aug 15:e175023.|Brain Res. 2022.|FEBS Open Bio. 2020 Sep;10(9):1880-1890.|Research Square Preprint. 2020 Dec.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12743A/K-7174-dihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12743A/K-7174-dihydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
191089-60-8
Available Sizes
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