FPTQ

FPTQ is potent mGluR1 antagonist with IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively[1]. FPTQ has anti-oxidant and anti-inflammatory effects in vitro and in vivo[2].

Product Specifications

CAS Number

[864863-72-9]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/FPTQ.html

Purity

99.92

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

FC(N=CC=C1)=C1N2N=NC(C3=CC4=C(C=C3)N=CC=C4)=C2C

Molecular Formula

C17H12FN5

Molecular Weight

305.31

References & Citations

[1]Fujinaga M et al. Synthesis and evaluation of 6-[1- (2-[ (18) F]fluoro-3-pyridyl) -5-methyl-1H-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain. Bioorg Med Chem, 2011 Jan 1, 19 (1) :102-10.|[2]Geum Ran Kim, et al. Anti-inflammatory effect of a novel synthetic compound 1- ((4-fluorophenyl) thio) isoquinoline in RAW264.7 macrophages and a zebrafish model. Fish Shellfish Immunol. 2019 Apr;87:395-400.