FPTQ
Product Specifications
UNSPSC Description
FPTQ is potent mGluR1 antagonist with IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively[1]. FPTQ has anti-oxidant and anti-inflammatory effects in vitro and in vivo[2].
Target Antigen
mGluR
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/FPTQ.html
Purity
99.92
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
FC(N=CC=C1)=C1N2N=NC(C3=CC4=C(C=C3)N=CC=C4)=C2C
Molecular Weight
305.31
References & Citations
[1]Fujinaga M et al. Synthesis and evaluation of 6-[1-(2-[(18)F]fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain. Bioorg Med Chem, 2011 Jan 1, 19(1):102-10.|[2]Geum Ran Kim, et al. Anti-inflammatory effect of a novel synthetic compound 1-((4-fluorophenyl)thio)isoquinoline in RAW264.7 macrophages and a zebrafish model. Fish Shellfish Immunol. 2019 Apr;87:395-400.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100382/FPTQ-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100382/FPTQ-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
864863-72-9
Available Sizes
Curated Selection
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