(R) -Tanimilast

(R) -Tanimilast is a isomeride of Tanimilast (HY-19929) . Tanimilast (CHF-6001) is a novel highly potent and selective phosphodiesterase 4 inhibitor (IC50=0.026 nM) [1].

Product Specifications

Product Name Alternative

(R) -CHF-6001

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/r-tanimilast.html

Purity

99.72

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(O[C@@H](C1=CC=C(OC(F)F)C(OCC2CC2)=C1)CC3=C(Cl)C=[N+]([O-])C=C3Cl)C4=CC=C(NS(=O)(C)=O)C(OCC5CC5)=C4

Molecular Formula

C30H30Cl2F2N2O8S

Molecular Weight

687.54

References & Citations

[1]Moretto N, et, al. CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration. J Pharmacol Exp Ther. 2015 Mar;352 (3) :559-67.