PACMA 31
PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC50 of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues[1]. PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
[1401089-31-3]
UNSPSC
12352005
Hazard Statement
H301
Target
PDI
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pacma-31.html
Purity
99.32
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=C(N(C(C2=CC=CS2)C(NCC(OCC)=O)=O)C(C#C)=O)C(OC)=C1
Molecular Formula
C21H22N2O6S
Molecular Weight
430.47
Precautions
H301
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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PIK3C2A, NT (Phosphoinositide-3-kinase Class 2 alpha Polypeptide, Phosphoinositide 3-kinase-C2-alpha, Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Subunit alpha, PI3K-C2-alpha, PI3-K-C2(alpha), PI3-K-C2A, PtdIns-3-kinase C2 Subunit alpha
PIK3C2A, NT (Phosphoinositide-3-kinase Class 2 alpha Polypeptide, Phosphoinositide 3-kinase-C2-alpha, Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Subunit alpha, PI3K-C2-alpha, PI3-K-C2(alpha), PI3-K-C2A, PtdIns-3-kinase C2 Subunit alpha
