What is the catalog number for Guaiol?

The catalog number for Guaiol is HY-N3980.

What sizes are available for Guaiol?

Guaiol is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg.

How many pack sizes does Guaiol come in?

Guaiol is available in 3 different pack sizes.

Guaiol is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Guaiol?

Guaiol is manufactured by QuantiMol.

What is the estimated delivery time for Guaiol?

Estimated delivery time for Guaiol is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Guaiol?

The safety data sheet for Guaiol is available here: http://file.medchemexpress.com/batch_PDF/HY-N3980/Guaiol-SDS-MedChemExpress.pdf.

Guaiol

Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC50 of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions[1][2][3][4][5][6].

Product Specifications

CAS Number

489-86-1

Product Name Alternative

Champacol; Guaiac alcohol

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; RAD51

Type

Natural Products

Related Pathways

Autophagy; Cell Cycle/DNA Damage

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/guaiol.html

Purity

99.67

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

C[C@@H]1C2=C([C@H](CC[C@@H](C(C)(O)C)C2)C)CC1

Molecular Formula

C15H26O

Molecular Weight

222.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Yang, Q, et al. (−) -Guaiol regulates RAD51 stability via autophagy to induce cell apoptosis in non-small cell lung cancer Oncotarget. 2016 Sep 20;7 (38) :62585-62597.|[2]Ali, A., Tabanca, et al. Chemical composition and biological activity of four salvia essential oils and individual compounds against two species of mosquitoes J. Agric. Food Chem. 63 (2), 447-456 (2015) .|[3]Liu, T, et al. Guaiol - a naturally occurring insecticidal sesquiterpene Nat. Prod. Commun. 8 (10), 1353-1354 (2013) .|[4]Garcia M C F, et al. The in vitro antileishmanial activity of essential oil from Aloysia gratissima and guaiol, its major sesquiterpene against Leishmania amazonensis[J]. Parasitology, 2018, 145 (9) : 1219-1227.|[5]Thurman E M. Analysis of terpenes in hemp (Cannabis sativa) by gas chromatography/mass spectrometry: Isomer identification analysis[M]//Comprehensive Analytical Chemistry. Elsevier, 2020, 90: 197-233.|[6]Yang M, et al. Determination and pharmacokinetic study of guaiol in rat plasma by gas chromatography–mass spectrometry with selected ion monitoring[J]. Journal of Chromatography B, 2018, 1085: 30-35.