PSB-1114 (triethylamine)

PSB-1114 triethylamine is a potent, enzymatically stable, and subtype-selective P2Y2 receptor agonist with an EC50 of 134 nM. PSB-1114 triethylamine displays >50-fold selectivity versus the P2Y4 (EC50 of 9.3 μM) and P2Y6 (EC50 of 7.0 μM) receptors[1].

Product Specifications

UNSPSC

12352128

Target

P2Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/psb-1114-triethylamine.html

Purity

95.0

Solubility

H2O : ≥ 100 mg/mL

Smiles

CCN(CC)CC.O[C@H]1[C@H](N2C(NC(C=C2)=S)=O)O[C@H](COP(OP(C(F)(F)P(O)(O)=O)(O)=O)(O)=O)[C@H]1O.[x]

Molecular Formula

C10H15F2N2O13P3S.xC6H15N

References & Citations

[1]El-Tayeb A, et al. Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2011 Apr 28;54 (8) :2878-90.