MGL-IN-1
MGL-IN-1 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. MGL-IN-1 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. MGL-IN-1 displays high membrane permeability and brain penetrant[1].
Product Specifications
CAS Number
1881244-28-5
UNSPSC
12352005
Target
MAGL
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mgl-in-1.html
Concentration
10mM
Purity
99.21
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C1N(C(CC2)CCN2C(N3C=NC=N3)=O)[C@@](C4=CC=C5C(OCO5)=C4)([H])[C@@]1([H])C(C=C6)=CC=C6F
Molecular Formula
C24H22FN5O4
Molecular Weight
463.46
References & Citations
[1]Brindisi M, et al. Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. J Med Chem. 2016 Mar 24;59 (6) :2612-32.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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