MGL-IN-1

MGL-IN-1 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. MGL-IN-1 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. MGL-IN-1 displays high membrane permeability and brain penetrant[1].

Product Specifications

CAS Number

[1881244-28-5]

UNSPSC

12352005

Target

MAGL

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mgl-in-1.html

Concentration

10mM

Purity

99.21

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C1N(C(CC2)CCN2C(N3C=NC=N3)=O)[C@@](C4=CC=C5C(OCO5)=C4)([H])[C@@]1([H])C(C=C6)=CC=C6F

Molecular Formula

C24H22FN5O4

Molecular Weight

463.46

References & Citations

[1]Brindisi M, et al. Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. J Med Chem. 2016 Mar 24;59 (6) :2612-32.