Cyclo (Phe-Pro)

Cyclo (Phe-Pro) (Cyclo (phenylalanylprolyl) ) is a quorum-sensing molecule of Vibrio vulnificus that specifically interacts with RIG-I, inhibiting RIG-I polyubiquitination, suppressing IRF-3 activation, and reducing type I interferon production. Cyclo (Phe-Pro) enhances susceptibility to HCV and influenza virus and also alleviates plant aluminum toxicity stress. The mechanism of Cyclo (Phe-Pro) involves the regulation of host immune signaling pathways, bacterial virulence gene expression, and plant antioxidant systems, making it a promising candidate for research in viral infections, bacterial virulence regulation, and agricultural stress resistance[1][2][3].

Product Specifications

CAS Number

[14705-60-3]

Product Name Alternative

Cyclo (phenylalanylprolyl) ; A-64863

UNSPSC

12352209

Hazard Statement

H302, H315, H319

Target

Antibiotic; Bacterial; HCV; Reactive Oxygen Species (ROS)

Type

Peptides

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Neuroscience-Neuromodulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/cyclo-phe-pro.html

Purity

98.77

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1NC(C(N2C1CCC2)=O)CC3=CC=CC=C3

Molecular Formula

C14H16N2O2

Molecular Weight

244.29

Precautions

H302, H315, H319

References & Citations

[1]Lee W, et al. Vibrio vulnificus quorum-sensing molecule cyclo (Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity. Nat Commun. 2018 Apr 23;9 (1) :1606.|[2]Bina XR, et al. The cyclic dipeptide cyclo (Phe-Pro) inhibits cholera toxin and toxin-coregulated pilus production in O1 El Tor Vibrio cholerae. J Bacteriol. 2010 Jul;192 (14) :3829-32.|[3]Wang Y, et al. Novel application of cyclo (-Phe-Pro) in mitigating aluminum toxicity through oxidative stress alleviation in wheat roots. Environ Pollut. 2024 Dec 15;363 (Pt 2) :125241.