Gestrinone
Gestrinone (R2323) is a synthetic steroid hormone used to treat endometriosis. It inhibits leiomyoma cells with an IC50 of 43.67 μM. Gestrinone is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
16320-04-0
Product Name Alternative
R 2323
UNSPSC
12352211
Hazard Statement
H361
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Gestrinone.html
Purity
99.76
Solubility
DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL
Smiles
C#C[C@]1(O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CCC4=C3C=C[C@]12CC)=O
Molecular Formula
C21H24O2
Molecular Weight
308.41
Precautions
H361
References & Citations
[1]Tamaya T, et al. Gestrinone (R2323) binding to steroid receptors in human uterine endometrial cytosol. Acta Obstet Gynecol Scand. 1986;65 (5) :439-41.|[2]Zhu Y, et al. Gestrinone inhibits growth of human uterine leiomyoma may relate to activity regulation of ERα, Src and P38 MAPK. Biomed Pharmacother. 2012 Dec;66 (8) :569-77.|[3]Snyder BW, et al. Studies on the mechanism of action of danazol and gestrinone (R2323) in the rat: evidence for a masked estrogen component. Fertil Steril. 1989 Apr;51 (4) :705-10.|[4]Dowsett M, et al. A comparison of the effects of danazol and gestrinone on testosterone binding to sex hormone binding globulin in vitro and in vivo. Clin Endocrinol (Oxf) . 1986 May;24 (5) :555-63.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
SSCSLM080GZ80AD0SOSE 1 Piece/Case:1 Piece/ PACKS:1 PACKS/CASE
S-Steel Cart, S-Steel S316L,80 mesh, Gen Purpose,868mm, OD:69mm, DOE, SS Steel, No-Seal Mat, Standard, Revision E
Sign In for Pricing
View Details 
MBS1326423-01 0.02 mg (E-Coli)
Recombinant Shigella flexneri Pyrimidine-specific ribonucleoside hydrolase RihA (rihA)
Sign In for Pricing
View Details MBS1326423-02 0.02 mg (Yeast)
Recombinant Shigella flexneri Pyrimidine-specific ribonucleoside hydrolase RihA (rihA)
Sign In for Pricing
View Details MBS1326423-03 0.1 mg (E-Coli)
Recombinant Shigella flexneri Pyrimidine-specific ribonucleoside hydrolase RihA (rihA)
Sign In for Pricing
View Details MBS1326423-04 0.1 mg (Yeast)
Recombinant Shigella flexneri Pyrimidine-specific ribonucleoside hydrolase RihA (rihA)
Sign In for Pricing
View Details