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Fenclonine (hydrochloride)

Fenclonine hydrochloride is a selective and irreversible tryptophan hydroxylase inhibitor, which is a rate-limiting enzyme in the biosynthesis of serotonin. Fenclonine hydrochloride can be used in carcinoid syndrome research[1][2][3].

Product Specifications

Product Name Alternative

4-Chloro-DL-phenylalanine (hydrochloride) ; PCPA (hydrochloride) ; CP-10188 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Tryptophan Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/fenclonine-hydrochloride.html

Concentration

10mM

Purity

98.60

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

O=C(C(CC1=CC=C(C=C1)Cl)N)O.Cl

Molecular Formula

C9H11Cl2NO2

Molecular Weight

236.10

Precautions

H302, H312, H332

References & Citations

[1]M Jouvet. Sleep and serotonin: an unfinished story. Neuropsychopharmacology. 1999 Aug;21 (2 Suppl) :24S-27S.|[2]A K Sanyal, et al. Prostaglandins: antinociceptive effect of prostaglandin E1 in the rat. Clin Exp Pharmacol Physiol. 1977 May-Jun;4 (3) :247-55.|[3]Shyamshree S S Manna, et al. Paracetamol potentiates the antidepressant-like and anticompulsive-like effects of fluoxetine. Behav Pharmacol. 2015 Apr;26 (3) :268-81.|[4]Zheng Y, et al. In silico Analysis and Experimental Validation of Lignan Extracts from Kadsura longipedunculata for Potential 5-HT1AR Agonists. PLoS One. 2015 Jun 15;10 (6) :e0130055.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-W772850/Fenclonine-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-W772850/Fenclonine-hydrochloride-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

CAS Number

[23633-07-0]

Available Sizes

Curated Selection

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