SB-269970 (hydrochloride)

SB-269970 hydrochloride is a potent, selective and brain-penetrant 5-HT7 receptor antagonist with a pKi of 8.3. SB-269970 hydrochloride exhibits >50-fold selectivity against other 5-HT receptors[1][2].

Product Specifications

CAS Number

[261901-57-9]

Product Name Alternative

SB-269970A

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sb-269970-hydrochloride.html

Purity

99.67

Solubility

DMSO : ≥ 100 mg/mL|H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC1=CC=CC(S(=O)(N2[C@@H](CCN3CCC(C)CC3)CCC2)=O)=C1.[H]Cl

Molecular Formula

C18H29ClN2O3S

Molecular Weight

388.95

References & Citations

[1]http://www.ncbi.nlm.nih.gov/pubmed/10821781|[2]Roberts C, et al. The effect of SB-269970, a 5-HT (7) receptor antagonist, on 5-HT release from serotonergic terminals and cell bodies. Br J Pharmacol. 2001 Apr;132 (7) :1574-80.|[3]Monti JM, et al. The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat. Behav Brain Res. 2008 Aug 22;191 (2) :184-9.