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Flupirtine (Standard)

Flupirtine (Standard) is the analytical standard of Flupirtine. This product is intended for research and analytical applications. 0

Product Specifications

Product Name Alternative

D 9998 (Standard)

UNSPSC

12352005

Target

IGluR; Potassium Channel; Reference Standards

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/flupirtine-standard.html

Smiles

O=C(NC1=CC=C(N=C1N)NCC2=CC=C(C=C2)F)OCC

Molecular Formula

C15H17FN4O2

Molecular Weight

304.32

References & Citations

[1]Kornhuber J, et al. Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltageindependent potassium channels. Rapid communication. J Neural Transm. 1999;106 (9-10) :857-67.|[2]Klinger F, et al. Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine. Br J Pharmacol. 2012 Jul;166 (5) :1631-42.|[3]Swedberg MD, et al. Pharmacological mechanisms of action of flupirtine: a novel, centrally acting, nonopioid analgesic evaluated by its discriminative effects in the rat. J Pharmacol Exp Ther. 1988 Sep;246 (3) :1067-74.|[4]Wu SN, et al. Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier k (+) currents in motor neuron-like cells. Evid Based Complement Alternat Med. 2012;2012:148403.|[5]Kolosov A, et al. Flupirtine enhances the anti-hyperalgesic effects of morphine in a rat model of prostate bone metastasis. Pain Med. 2012 Nov;13 (11) :1444-56.|[6]Michel MC, et al. Unexpected frequent hepatotoxicity of a prescription drug, flupirtine, marketed for about 30 years. Br J Clin Pharmacol. 2012 May;73 (5) :821-5.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-17001AR/Flupirtine-Standard-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-17001AR/

Scientific Category

Reference Standards

CAS Number

[56995-20-1]

Available Sizes

Curated Selection

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