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AZSMO-23

AZSMO-23 is a potent hERG K+ channel activator. AZSMO-23 activats WT hERG pre-pulse and tail current with EC50 values of 28.6, 11.2 µM, respectively. AZSMO-23 has the potential for the research of long QT syndrome[1].

Product Specifications

CAS Number

496793-75-0

UNSPSC

12352005

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/azsmo-23.html

Purity

99.87

Solubility

DMSO : 5.83 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=CN=C1)NC2=CC=C(Cl)C(C3=NC4=CC=CC=C4N3)=C2

Molecular Formula

C19H13ClN4O

Molecular Weight

348.79

References & Citations

[1]Mannikko R, et al. Pharmacological and electrophysiological characterization of AZSMO-23, an activator of the hERG K (+) channel. Br J Pharmacol. 2015 Jun;172 (12) :3112-25.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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