AZSMO-23
AZSMO-23 is a potent hERG K+ channel activator. AZSMO-23 activats WT hERG pre-pulse and tail current with EC50 values of 28.6, 11.2 µM, respectively. AZSMO-23 has the potential for the research of long QT syndrome[1].
Product Specifications
CAS Number
496793-75-0
UNSPSC
12352005
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/azsmo-23.html
Purity
99.87
Solubility
DMSO : 5.83 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=CN=C1)NC2=CC=C(Cl)C(C3=NC4=CC=CC=C4N3)=C2
Molecular Formula
C19H13ClN4O
Molecular Weight
348.79
References & Citations
[1]Mannikko R, et al. Pharmacological and electrophysiological characterization of AZSMO-23, an activator of the hERG K (+) channel. Br J Pharmacol. 2015 Jun;172 (12) :3112-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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