Revefenacin

Revefenacin (TD-4208; GSK1160724) is a potent mAChR antagonist; has a high affinity on M3 receptor with a Ki of 0.18 nM.

Product Specifications

CAS Number

[864750-70-9]

Product Name Alternative

TD-4208; GSK1160724

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Revefenacin.html

Purity

99.09

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OC1CCN(CCN(C(C2=CC=C(CN3CCC(C(N)=O)CC3)C=C2)=O)C)CC1)NC4=CC=CC=C4C5=CC=CC=C5

Molecular Formula

C35H43N5O4

Molecular Weight

597.75

Precautions

H302, H315, H319, H335

References & Citations

[1]Steinfeld T, et al. In vitro characterization of TD-4208, a lung-selective and long-acting muscarinic antagonist bronchodilator (Abstract) . Am J Respir Crit Care Med 179:A4553.|[2]Pulido-Rios MT, et al. In vivo pharmacological characterization of TD-4208, a novel lung-selective inhaled muscarinic antagonist with sustained bronchoprotective effect in experimental animal models. J Pharmacol Exp Ther. 2013 Aug;346 (2) :241-50.