NSC 66811
NSC 66811 is a MDM2-p53 inhibitor, with a Ki of 120 nM for binding to MDM2[1].
Product Specifications
CAS Number
6964-62-1
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc-66811.html
Concentration
10mM
Purity
98.12
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C2N=C(C)C=CC2=CC=C1C(C3=CC=CC=C3)NC4=CC=CC=C4
Molecular Formula
C23H20N2O
Molecular Weight
340.42
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Yipin Lu, et al. Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2) -p53 interaction through an integrated, virtual database screening strategy. J Med Chem. 2006 Jun 29;49 (13) :3759-62.|[2]Sanjeev Shangary, et al. Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy. Annu Rev Pharmacol Toxicol. 2009;49:223-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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