NSC 66811

NSC 66811 is a MDM2-p53 inhibitor, with a Ki of 120 nM for binding to MDM2[1].

Product Specifications

CAS Number

[6964-62-1]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nsc-66811.html

Concentration

10mM

Purity

98.12

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=C2N=C(C)C=CC2=CC=C1C(C3=CC=CC=C3)NC4=CC=CC=C4

Molecular Formula

C23H20N2O

Molecular Weight

340.42

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Yipin Lu, et al. Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2) -p53 interaction through an integrated, virtual database screening strategy. J Med Chem. 2006 Jun 29;49 (13) :3759-62.|[2]Sanjeev Shangary, et al. Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy. Annu Rev Pharmacol Toxicol. 2009;49:223-41.