KWCN-41

KWCN-41 is a selective and efficient inhibitor of RIPK1 kinase with an IC50 value of 88 nM. KWCN-41 specifically inhibits cell necrosis but does not inhibit apoptosis. KWCN-41 also has anti-inflammatory effects[1].

Product Specifications

CAS Number

[2913223-17-1]

UNSPSC

12352005

Target

Mixed Lineage Kinase; Necroptosis; RIP kinase

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/kwcn-41.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1CCOCC1)C2=CC=C(C3=CC4=C(N3)N=CC=C4)C=C2

Molecular Formula

C18H17N3O2

Molecular Weight

307.35

References & Citations

[1]Cui N, et al. Discovery of Sibiriline derivatives as novel receptor-interacting protein kinase 1 inhibitors. Eur J Med Chem. 2023 Mar 15;250:115190.