Ponatinib (hydrochloride)
Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively[1].
Product Specifications
CAS Number
[1114544-31-8]
Product Name Alternative
AP24534 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H301, H313, H333, H335, H361, H372
Target
Autophagy; Bcr-Abl; FGFR; PDGFR; Src; VEGFR
Type
Reference compound
Related Pathways
Autophagy; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/ponatinib-hydrochloride.html
Purity
99.76
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C(C)C(C#CC2=CN=C3C=CC=NN23)=C1)NC4=CC=C(CN5CCN(CC5)C)C(C(F)(F)F)=C4.Cl
Molecular Formula
C29H28ClF3N6O
Molecular Weight
569.02
Precautions
H301, H313, H333, H335, H361, H372
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Abl; PDGFRα; VEGFR2/KDR/Flk-1
Citation 01
Available Sizes
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