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Ponatinib (hydrochloride)

Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively[1].

Product Specifications

CAS Number

[1114544-31-8]

Product Name Alternative

AP24534 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H301, H313, H333, H335, H361, H372

Target

Autophagy; Bcr-Abl; FGFR; PDGFR; Src; VEGFR

Type

Reference compound

Related Pathways

Autophagy; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/ponatinib-hydrochloride.html

Purity

99.76

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=C(C)C(C#CC2=CN=C3C=CC=NN23)=C1)NC4=CC=C(CN5CCN(CC5)C)C(C(F)(F)F)=C4.Cl

Molecular Formula

C29H28ClF3N6O

Molecular Weight

569.02

Precautions

H301, H313, H333, H335, H361, H372

References & Citations

[1]O'Hare T, et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell, 2009, 16 (5), 401-412.|[2]Gover-Proaktor A, et al. Ponatinib reduces viability, migration, and functionality of human endothelial cells. Leuk Lymphoma. 2017 Jun;58 (6) :1455-1467.|[3]Hong YP, et al. Effects of Castanospermine on Inflammatory Response in a Rat Model of Experimental Severe Acute Pancreatitis. Arch Med Res. 2016 Aug;47 (6) :436-445.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Abl; PDGFRα; VEGFR2/KDR/Flk-1

Citation 01

Biomaterials. 2022 Oct:289:121800.|Acta Pharm Sin B. 2023 Oct;13 (10) :4253-4272.|Acta Pharmacol Sin. 2021 Jan;42 (1) :108-114.|Biochem Pharmacol. 2021 Oct:192:114710.|Biomed Pharmacother. 2024 Nov:180:117569.|Biomed Pharmacother. 2025 Jun 20:189:118246.|Biomolecules. 2022 Jun 11;12 (6) :819.|bioRxiv. 2024 Apr 21.|bioRxiv. 2025 February 26.|bioRxiv. 2025 May 5:2025.04.30.651490.|bioRxiv. 2025 Sep 30.|Blood Vessel Thromb Hemost. 2025 Nov 17.|BMC Chem. 2025 Aug 22;19 (1) :248.|Cancer Discov. 2021 Jan;11 (1) :126-141.|Cancer Sci. 2025 Apr;116 (4) :1115-1125.|Cell Rep Med. 2025 Apr 2:102053.|Clin Chim Acta. 2018 May:480:180-185.|Commun Biol. 2024 Jul 10;7 (1) :843.|Eur J Pharmacol. 2020 Dec 15;889:173292.|Exp Hematol. 2014 May;42 (5) :369-379.e3.|Fundam Clin Pharmacol. 2021 Oct;35 (5) :919-929.|Harvard Medical School LINCS LIBRARY|Heliyon. 2024 Sep 28;10 (19) :e38637.|Int J Biol Macromol. 2024 Dec 2:138305.|J Chem Eng Data. 2024 Jun 10.|J Ethnopharmacol. 2023 Jun 12:309:116275.|J Ethnopharmacol. 2024 Apr 6:323:117669.|J Ethnopharmacol. 2025 Sep 17;355 (Pt A) :120621.|J Hypertens. 2025 May 1;43 (5) :827-840.|J Inflamm Res. 2025 Jun 26:18:8447-8475.|J Med Chem. 2019 May 23;62 (10) :5006-5024. |J Med Chem. 2024 Nov 28;67 (22) :20571-20579.|Leuk Res. 2016 Jun:45:24-32.|Neurosci Bull. 2020 Mar;36 (3) :263-276.|Pharmaceuticals (Basel) . 2022 Aug 29;15 (9) :1073.|Pharmacogn Mag. 2023 Jul 20.|PLoS One. 2021 Sep 30;16 (9) :e0258140.|PLoS One. 2022 Feb 14;17 (2) :e0263822.|PLoS One. 2024 Nov 1;19 (11) :e0308647.|Research Square Preprint. 2021 May.|Research Square Print. 2023 Mar 23.|Sci Rep. 2025 Jul 2;15 (1) :22961.|Sci Rep. 2025 Oct 16;15 (1) :36227.|Sci Transl Med. 2018 Jul 18;10 (450) :eaaq1093.|Target Oncol. 2020 Oct;15 (5) :659-671.|Technical University of Munich. 24.01.2018.|University of Pittsburgh. 2025.

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