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Amisulpride-d5

Amisulpride-d5 is the deuterium labeled Amisulpride. Amisulpride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively[1][2].

Product Specifications

CAS Number

1216626-17-3

Product Name Alternative

(Rac) -Aramisulpride-d5; (Rac) -Esamisulpride-d5; DAN 2163-d5

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Dopamine Receptor

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Cancer; Neurological Disease

Purity

98.83

Solubility

DMSO : 50mg/mL (ultrasonic) |H2O : 0.2mg/mL (ultrasonic)

Smiles

[2H]C([2H])([2H])C([2H])([2H])N(CCC1)C1CNC(C2=C(C=C(C(S(CC)(=O)=O)=C2)N)OC)=O

Molecular Formula

C17H22D5N3O4S

Molecular Weight

374.51

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Schoemaker H, et al. Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity. 
 J Pharmacol Exp Ther. 1997 Jan;280 (1) :83-97.|[3]Pawar GR, et al. Evaluation of antidepressant like property of amisulpride per se and its comparison with fluoxetine and olanzapine using forced swimming test in albino mice. Acta Pol Pharm. 2009 May-Jun;66 (3) :327-31.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Isoform

D3 Receptor

Available Sizes

Frequently Asked Questions

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