ABBV-318
ABBV-318 is a potent Nav1.7/ Nav1.8 blocker, with IC50s of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8, respectively. ABBV-318 can be used for the research of pain[1].
Product Specifications
CAS Number
1802848-94-7
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/abbv-318.html
Concentration
10mM
Purity
98.72
Solubility
DMSO : 166.67 mg/mL (ultrasonic)
Smiles
O=C(N1C[C@H](F)CC1)C2=NC3=CC=C(OC4=NC=C(C(F)(F)F)C=C4)C=C3C=C2
Molecular Formula
C20H15F4N3O2
Molecular Weight
405.35
References & Citations
[1]Patel MV, et, al. Discovery of (R) - (3-fluoropyrrolidin-1-yl) (6- ((5- (trifluoromethyl) pyridin-2-yl) oxy) quinolin-2-yl) methanone (ABBV-318) and analogs as small molecule Na v 1.7/ Nav1.8 blockers for the treatment of pain. Bioorg Med Chem. 2022 Jun 1;63:116743.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.7; Nav1.8
Available Sizes
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