ABBV-318

ABBV-318 is a potent Nav1.7/ Nav1.8 blocker, with IC50s of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8, respectively. ABBV-318 can be used for the research of pain[1].

Product Specifications

CAS Number

[1802848-94-7]

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/abbv-318.html

Concentration

10mM

Purity

98.72

Solubility

DMSO : 166.67 mg/mL (ultrasonic)

Smiles

O=C(N1C[C@H](F)CC1)C2=NC3=CC=C(OC4=NC=C(C(F)(F)F)C=C4)C=C3C=C2

Molecular Formula

C20H15F4N3O2

Molecular Weight

405.35

References & Citations

[1]Patel MV, et, al. Discovery of (R) - (3-fluoropyrrolidin-1-yl) (6- ((5- (trifluoromethyl) pyridin-2-yl) oxy) quinolin-2-yl) methanone (ABBV-318) and analogs as small molecule Na v 1.7/ Nav1.8 blockers for the treatment of pain. Bioorg Med Chem. 2022 Jun 1;63:116743.