Nisoxetine (hydrochloride)
Product Specifications
UNSPSC Description
Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine hydrochloride is an antidepressant and local anesthetic, it can block voltage-gated sodium channels[1][2][3].
Target Antigen
Monoamine Transporter; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nisoxetine-hydrochloride.html
Purity
99.81
Solubility
DMSO : 250 mg/mL (ultrasonic)|H2O : 8.33 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CNCCC(OC1=CC=CC=C1OC)C2=CC=CC=C2.[H]Cl
Molecular Weight
307.82
References & Citations
[1]Béïque JC, et, al. Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters. Eur J Pharmacol. 1998 May 15; 349(1): 129-32.|[2]Cheetham SC, et, al. [3H]nisoxetine-a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology. 1996 Jan; 35(1): 63-70.|[3]Leung YM, et, al. Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats. Pharmacol Rep. 2013; 65(2): 350-7.|[4]Bello NT, et al. High-fat diet-induced alterations in the feeding suppression of low-dose nisoxetine, a selective norepinephrine reuptake inhibitor. J Obes. 2013;2013:457047.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B1704A/Nisoxetine-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B1704A/Nisoxetine-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
57754-86-6
Available Sizes
Curated Selection
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