Nisoxetine (hydrochloride)

Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine hydrochloride is an antidepressant and local anesthetic, it can block voltage-gated sodium channels[1][2][3].

Product Specifications

CAS Number

[57754-86-6]

UNSPSC

12352005

Target

Monoamine Transporter; Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nisoxetine-hydrochloride.html

Purity

99.92

Solubility

DMSO : 250 mg/mL (ultrasonic) |H2O : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CNCCC(OC1=CC=CC=C1OC)C2=CC=CC=C2.[H]Cl

Molecular Formula

C17H22ClNO2

Molecular Weight

307.82

References & Citations

[1]Béïque JC, et, al. Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters. Eur J Pharmacol. 1998 May 15; 349 (1) : 129-32.|[2]Cheetham SC, et, al. [3H]nisoxetine-a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology. 1996 Jan; 35 (1) : 63-70.|[3]Leung YM, et, al. Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats. Pharmacol Rep. 2013; 65 (2) : 350-7.|[4]Bello NT, et al. High-fat diet-induced alterations in the feeding suppression of low-dose nisoxetine, a selective norepinephrine reuptake inhibitor. J Obes. 2013;2013:457047.