RSVA405
RSVA405 is a potent, orally active activator of AMPK, with an EC50 of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 can also be used for the research of obesity[1][2][3][4].
Product Specifications
CAS Number
140405-36-3
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
AMPK; Autophagy; STAT
Type
Reference compound
Related Pathways
Autophagy; Epigenetics; JAK/STAT Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rsva405.html
Purity
99.72
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=NC=C1)N/N=C/C2=CC=C(N(CC)CC)C=C2O
Molecular Formula
C17H20N4O2
Molecular Weight
312.37
Precautions
H302, H312, H332
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPK
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
UBFD1, NT (UBFD1, UBPH, Ubiquitin domain-containing protein UBFD1, Ubiquitin-binding protein homolog) (PE)
UBFD1, NT (UBFD1, UBPH, Ubiquitin domain-containing protein UBFD1, Ubiquitin-binding protein homolog) (PE)
MYPOP sgRNA CRISPR Lentivector (Human) (Target 1)