RSVA405
RSVA405 is a potent, orally active activator of AMPK, with an EC50 of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 can also be used for the research of obesity[1][2][3][4].
Product Specifications
CAS Number
140405-36-3
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
AMPK; Autophagy; STAT
Type
Reference compound
Related Pathways
Autophagy; Epigenetics; JAK/STAT Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rsva405.html
Purity
99.72
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=NC=C1)N/N=C/C2=CC=C(N(CC)CC)C=C2O
Molecular Formula
C17H20N4O2
Molecular Weight
312.37
Precautions
H302, H312, H332
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPK
Available Sizes
Frequently Asked Questions
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