Diaplasinin
Diaplasinin (PAI-749) is a plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 295 nM. Diaplasinin has antithrombotic efficacy[1].
Product Specifications
CAS Number
[481631-45-2]
Product Name Alternative
PAI-749
UNSPSC
12352005
Target
PAI-1
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/diaplasinin.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CCCCCC1=C(N(C2=C1C=CC=C2)CC3=CC=CC=C3)C4=CC=C5C=C(C=CC5=C4)OCC6=NN=NN6
Molecular Formula
C32H31N5O
Molecular Weight
501.62
References & Citations
[1]A J Lucking, et al. Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis. J Thromb Haemost. 2010 Jun;8 (6) :1333-9.|[2]Stephen J Gardell, et al. Neutralization of plasminogen activator inhibitor I (PAI-1) by the synthetic antagonist PAI-749 via a dual mechanism of action. Mol Pharmacol. 2007 Oct;72 (4) :897-906.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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