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BC11-38

BC11-38 is a potent, selective, and biologically active PDE11 inhibitor, with IC50s of 0.28 µM and >100 µM for PDE11 and PDE1-10, respectively. BC11-38 elevates cAMP levels, PKA-mediated ATF-1 phosphorylation, and cortisol production in H295R cells[1].

Product Specifications

CAS Number

686770-80-9

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/bc11-38.html

Purity

99.42

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C1C2=C(CCS2)N=C(SCCC)N1C3=CC=CC=C3

Molecular Formula

C15H16N2OS2

Molecular Weight

304.43

References & Citations

[1]Ceyhan O, et al. Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chem Biol. 2012;19 (1) :155-163.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PDE10; PDE11

Available Sizes

Frequently Asked Questions

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