XY1

XY1 is an analog of SGC707 (HY-19715), a potent and selective PRMT3 inhibitor with an IC50 of 31 nM. XY1 is completely inactive against PRMT3. XY1 and SGC707 represent an excellent pair of tools for further elucidating the biological functions and disease relevance of PRMT3[1].

Product Specifications

CAS Number

[1624117-53-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/XY1.html

Purity

99.10

Solubility

DMSO : 67.5 mg/mL (ultrasonic)

Smiles

O=C(NCC(N1CCCC1)=O)NC2=CC=C3C=CC=CC3=C2

Molecular Formula

C17H19N3O2

Molecular Weight

297.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Kaniskan H?, et al. A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) . Angew Chem Int Ed Engl. 2015 Apr 20;54 (17) :5166-70.