WRN inhibitor 20
WRN inhibitor 20 (Compound 14c) is a WRN degrader demonstrating significant degradation activity in various cells, including HCT-116 (DC50 = 1.7 μM), SW-48 (DC50 = 3.0 μM), and SW-480 (DC50 = 5.9 μM) . This compound shows strong antiproliferative effects, promotes apoptosis, inhibits migration, and induces DNA damage in MSI-H cells, making it a valuable tool for cancer research.
Product Specifications
CAS Number
3095277-20-3
Smiles
O=C (NC1=CC=C (C=C1) C) CNS (=O) (=O) C2=NC (=CC (=N2) C (F) (F) F) C=3C=CC (OCCCCCNC (=O) CC45CC6CC (CC (C6) C4) C5) =CC3
Molecular Formula
C37H44F3N5O5S
Molecular Weight
727.84
Notes
For research use only.
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