HQ005
HQ005 is a potent CCNK molecular-glue degrader with an DC50 value of 0.041 µM. HQ005 mediates interactions between target proteins and components of the ubiquitin-proteasome system to cause selective protein degradation[1].
Product Specifications
CAS Number
[2750644-31-4]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
CDK; Molecular Glues
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hq005.html
Purity
99.51
Solubility
10 mM in DMSO
Smiles
O=C(CC1=CSC(NC2=CC=CC(CO)=N2)=N1)NC3=NC=C(C)S3
Molecular Formula
C15H15N5O2S2
Molecular Weight
361.44
Precautions
H315, H319, H335
References & Citations
[1]Lv L, et al. Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. Elife. 2020 Aug 17;9:e59994.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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