8-Nitroguanine
8-Nitroguanine, a product of nitrative DNA damage caused by reactive nitrogen species, is a potential biomarker for progression of malignant fibrous histiocytoma[1][2].
Product Specifications
CAS Number
168701-80-2
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/8-nitroguanine.html
Solubility
10 mM in DMSO
Smiles
O=C1N=C(N)NC2=C1NC([N+]([O-])=O)=N2
Molecular Formula
C5H4N6O3
Molecular Weight
196.12
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
References & Citations
[1]Hiroshi Ohshima, et al. 8-nitroguanine, a product of nitrative DNA damage caused by reactive nitrogen species: formation, occurrence, and implications in inflammation and carcinogenesis. Antioxid Redox Signal. 2006 May-Jun;8 (5-6) :1033-45.|[2]Yoko Hoki, et al. 8-Nitroguanine as a potential biomarker for progression of malignant fibrous histiocytoma, a model of inflammation-related cancer. Oncol Rep. 2007 Nov;18 (5) :1165-9.|[3]Yusuke Hiraku, et al. Formation of 8-nitroguanine, a nitrative DNA lesion, in inflammation-related carcinogenesis and its significance. Environ Health Prev Med. 2010 Mar;15 (2) :63-72.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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